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Clinical Trials News

Open Protocols
10/05/2009

Brain

ECOG E-1F05 (IRB# 07-195): Phase II Study of Rituximab [ ...read more]
Given in Conjunction with Standard Chemotherapy in Primary Central Nervous System (CNS) Lymphoma.
Links: Official web site

RTOG 0614 (IRB# 08-102): A Randomized, Phase III, [ ...read more]
Double-Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy.
Links: Official web site

Breast

CALGB 40502 (IRB# 09-034): A Randomized Phase III Trial [ ...read more]
of Weekly Paclitaxel Compared to Weekly Nanoparticle Albumin Bound Nab-Paclitaxel or Ixabepilone Combined with Bevacizumab As First-Line Therapy for Locally Recurrent or Metastatic Breast Cancer.
Links: Official web site

ECOG E-1105 (IRB# 08-023): A Randomized Phase III Double-Blind [ ...read more]
Placebo-Controlled Trial of First-Line Chemotherapy and Trastuzumab with or without Bevacizumab for Patients with HER-2/NEU Over-Expressing Metastatic Breast Cancer.
Links: Official web site

ECOG PACCT-1 (IRB# 06-223): Program for the assessment [ ...read more]
of Clinical Cancer Test: Trial Assigning Individualized Options for the Treatment: The TAILORx Trial.
Links: Official web site

NSABP B-40 (IRB# 06-241): A Randomized Phase III Trial [ ...read more]
of Neoadjuvant Therapy in Patients with Palpable and Operable Breast Cancer Evaluating the Effect on Pathologic Complete Response (pCR) of Adding Capecitabine or Gemcitabine to Docetaxel when Administered Before AC with or without Bevacizumab and Correlative Science Studies Attempting to Identify Predictors of High Likelihood for pCR with Each of the Regimens.
Links: Official web site

NSABP B-43 (IRB# 09-066): A Phase III Clinical Trial [ ...read more]
Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected By Lumpectomy.
Links: Official web site

NSABP B-44 (BETH) (IRB# 08-060): A Multicenter Phase III Randomized Trial [ ...read more]
of Adjuvant Therapy for Patients with HER2-Positive Node-Positive or High Risk Node-Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab with Chemotherapy Plus Trastuzumab Plus Bevacizumab.
Links: Official web site

UofC BRCA1 (IRB# 05-240): Inactivation and Breast Cancer Risk. [ ...read more]
This study is researching breast and ovarian cancer in African-American families who have a personal or family history of these forms of cancer. The purpose of this research study is to increase our understanding of the genetic, environmental and medical risk factors associated with breast and ovarian cancer. We are studying individuals with these cancers and their relatives to identify factors which may affect the risk of breast and/or ovarian cancer. These factors may be identified through analysis of questionnaire data and DNA samples (extracted from blood). If people at greatest risk of developing breast or ovarian cancer were identified early, actions can be taken in hopes of preventing or better controlling the disease.
Links: Official web site

Colorectal

CALGB 80405 (IRB# 06-196): A Phase III Trial [ ...read more]
of Irinotecan/5-FU/Leucovorin or Oxaliplatin/5-FU/Leucovorin with Bevacizumab, or Cetuximab (C225), or with the combination of Bevacizumab and Cetuximab for patients with untreated metastatic adenocarcinoma of the colon or rectum.
Links: Official web site

NCCTG N0147 (IRB# 07-099): A Randomized Phase III Trial of [ ...read more]
Oxaliplatin (OXAL) Plus 5-Fluorouracil (5-FU)/Leucovorin (CF) with or without Cetuximab (C225) after Curative Resection for Patients with Stage III Colon Cancer.
Links: Official web site

NSABP R-04 (IRB# 05-012): A Clinical Trial Comparing [ ...read more]
Preoperative Radiation Therapy and Capecitabine with Preoperative Radiation Therapy and Continuous Intravenous Infusion (CVI) of 5-Fluorouracil (5-FU) in the Treatment of Patients with Operable Carcinoma of the Rectum.
Links: Official web site

Gyne

IUFD Study (IRB# 08-080): Misoprostol for Treatment of Fetal Death [ ...read more]
at 14-28 Weeks of Pregnancy, Inclusive, not Accompanied by Complete Expulsion of the Contents of the Uterus.

Head-Neck

ECOG E-1305 (IRB# 09-019): A Phase III Randomized [ ...read more]
Trial of Chemotherapy With or Without Bevacizumab in Patients with Recurrent or Metastatic Head and Neck Cancer.
Links: Official web site

RTOG 0436 (IRB# 08-158): A Phase III Trial Evaluating [ ...read more]
the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients With Esophageal Cancer Who Are Treated Without Surgery.
Links: Official web site

RTOG 0537 (IRB# 08-175): A Phase II/III Study Comparing [ ...read more]
Acupuncture-like Transcutaneous Electrical Nerve Stimulation (ALTENS) Versus Pilocarpine in Treating Early Radiation-Induced Xerostomi.
Links: Official web site

RTOG 0619 (IRB# 09-037): A Randomized Phase II [ ...read more]
Trial Of Chemoradiotherapy Versus Chemoradiotherapy And Vandetanib For High-Risk Postoperative Advanced Squamous Cell Carcinoma Of The Head And Neck.
Links: Official web site

Lung

ECOG E-1505 (IRB# 09-017): A Phase III Randomized Trial [ ...read more]
of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (=4 cm)-IIIA Non-Small Cell Lung Cancer (NSCLC).
Links: Official web site

ECOG E-5597 (IRB# 05-013): Phase III Chemoprevention Trial [ ...read more]
of Selenium Supplementation in Persons with Resected Stage I Non-Small Cell Lung Cancer.
Links: Official web site

RTOG 0617 (IRB# 07-201): A Randomized Phase III Comparison [ ...read more]
of Standard-Dose (60 Gy) Versus High-Dose (74 Gy) Conformal Radiotherapy With Concurrent And Consolidation Carboplatin/Paclitaxel In Patients With Stage IIIA/IIIB Non-Small Cell Lung Cancer.
Links: Official web site

Prostate

RTOG 0534 (IRB# 08-062): A Phase III Trial [ ...read more]
of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (Spport) in Prostate Cancer Patients with a Rising PSA after Radical Prostatectomy.
Links: Official web site

Renal

ECOG E-2805 (ASSURE) (IRB# 08-071): ASSURE: Adjuvant Sorafenib [ ...read more]
or Sunitinib for Unfavorable Renal Carcinoma.
Links: Official web site

Multiple Sites

MOFFITT HLMCC 0501 (IRB# 07-043): Stress Management Therapy for Patients Undergoing Chemotherapy. [ ...read more]
Links: Official web site

RTOG 0433 (NCIC CTG SC.20) (IRB# 07-137): A Phase III International Randomized Trial [ ...read more]
of Single Versus Multiple Fractions for Re-Irradiation of Painful Bone Metastases.
Links: Official web site

RTOG 0517 (IRB# 07-138): Randomized Phase III Trial to Evaluate [ ...read more]
Radiopharmaceuticals and Zoledronic Acid in the Palliation of Osteoblastic Metastases from Lung, Breast, and Prostate Cancer.
Links: Official web site

Pending Protocols
10/05/2009

RTOG 0825 - Phase III Double-Blind Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab Versus Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma.

CALGB 10404 - A Randomized Phase II Study of Three Fludarabine/Antibody Combinations for Patients with Symptomatic Previosuly Untreated Chronic Lymphocytic Leukemia.

RTOG 0841 - Efficiency of Screening for Depression in Cancer Patients Receiving Radiotherapy.

CCCWFU 97405 - Randomized Study of Soy Protein and Effexor on Vasomotor Symptoms of Men with Prostate Cancer.